1sbu

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[[Image:1sbu.gif|left|200px]]
 
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==NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2==
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The line below this paragraph, containing "STRUCTURE_1sbu", creates the "Structure Box" on the page.
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<StructureSection load='1sbu' size='340' side='right'caption='[[1sbu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sbu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_ermineus Conus ermineus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SBU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MT:(4R)-2,2-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>2MT</scene></td></tr>
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{{STRUCTURE_1sbu| PDB=1sbu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbu OCA], [https://pdbe.org/1sbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sbu RCSB], [https://www.ebi.ac.uk/pdbsum/1sbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sbu ProSAT]</span></td></tr>
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</table>
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'''NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2'''
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13 unit or the natural proline residue. NMR studies in water and molecular modeling allowed us to identify the amide bond "locked" in a cis conformation for as in the suggested bioactive form of the natural toxin.
The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13 unit or the natural proline residue. NMR studies in water and molecular modeling allowed us to identify the amide bond "locked" in a cis conformation for as in the suggested bioactive form of the natural toxin.
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==About this Structure==
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A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog.,Chierici S, Jourdan M, Figuet M, Dumy P Org Biomol Chem. 2004 Sep 7;2(17):2437-41. Epub 2004 Aug 5. PMID:15326523<ref>PMID:15326523</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog., Chierici S, Jourdan M, Figuet M, Dumy P, Org Biomol Chem. 2004 Sep 7;2(17):2437-41. Epub 2004 Aug 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15326523 15326523]
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</div>
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[[Category: Chierici, S.]]
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<div class="pdbe-citations 1sbu" style="background-color:#fffaf0;"></div>
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[[Category: Dumy, P.]]
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== References ==
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[[Category: Figuet, M.]]
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<references/>
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[[Category: Jourdan, M.]]
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__TOC__
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[[Category: Dimethyl-thiazolidine]]
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</StructureSection>
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[[Category: Molecular dynamics simulation]]
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[[Category: Conus ermineus]]
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[[Category: Nmr spectroscopy]]
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[[Category: Large Structures]]
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[[Category: Vi beta turn]]
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[[Category: Chierici S]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:31:26 2008''
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[[Category: Dumy P]]
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[[Category: Figuet M]]
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[[Category: Jourdan M]]

Current revision

NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2

PDB ID 1sbu

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