8p5g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:17, 5 June 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8p5g is ON HOLD until Paper Publication
+
==Kinase domain of wild type human ULK1 in complex with compound CCT241533==
-
 
+
<StructureSection load='8p5g' size='340' side='right'caption='[[8p5g]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
-
Authors: Battista, T., Semrau, M.S., Heroux, A., Lolli, G., Storici, P.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8p5g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P5G FirstGlance]. <br>
-
Description: Kinase domain of wild type human ULK1 in complex with compound CCT241533
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.019&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=XBJ:4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL)PYRROLIDIN-3-YL]AMINO}-6,7-DIMETHOXYQUINAZOLIN-2-YL)PHENOL'>XBJ</scene></td></tr>
-
[[Category: Storici, P]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p5g OCA], [https://pdbe.org/8p5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p5g RCSB], [https://www.ebi.ac.uk/pdbsum/8p5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p5g ProSAT]</span></td></tr>
-
[[Category: Lolli, G]]
+
</table>
-
[[Category: Heroux, A]]
+
== Function ==
-
[[Category: Semrau, M.S]]
+
[https://www.uniprot.org/uniprot/ULK1_HUMAN ULK1_HUMAN] Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.<ref>PMID:18936157</ref> <ref>PMID:21460634</ref> <ref>PMID:21795849</ref>
-
[[Category: Battista, T]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Battista T]]
 +
[[Category: Heroux A]]
 +
[[Category: Lolli G]]
 +
[[Category: Semrau MS]]
 +
[[Category: Storici P]]

Current revision

Kinase domain of wild type human ULK1 in complex with compound CCT241533

PDB ID 8p5g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8p5g"
Personal tools