8rhs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the ZnF domain from human Roquin-1== | |
| - | + | <StructureSection load='8rhs' size='340' side='right'caption='[[8rhs]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8rhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RHS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rhs OCA], [https://pdbe.org/8rhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rhs RCSB], [https://www.ebi.ac.uk/pdbsum/8rhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rhs ProSAT]</span></td></tr> |
| - | [[Category: Schlundt | + | </table> |
| - | [[Category: Tants | + | == Function == |
| + | [https://www.uniprot.org/uniprot/RC3H1_HUMAN RC3H1_HUMAN] Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schlundt A]] | ||
| + | [[Category: Tants JN]] | ||
Current revision
Structure of the ZnF domain from human Roquin-1
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