8s42

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Current revision (07:56, 5 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8s42 is ON HOLD until Paper Publication
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==Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 80 (1124898)==
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<StructureSection load='8s42' size='340' side='right'caption='[[8s42]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Konstantinidou, M., Vickery, H., Pennings, M.A.M., Virta, J., Visser, E.J., Oetelaar, M.C.M., Overmans, M., Neitz, J., Ottmann, C., Brunsveld, L., Arkin, M.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8s42]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S42 FirstGlance]. <br>
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Description: Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 80 (1124898)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H5F:2-chloranyl-1-[8-[3-fluoranyl-4-(trifluoromethyl)phenyl]sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]ethanone'>A1H5F</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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[[Category: Konstantinidou, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s42 OCA], [https://pdbe.org/8s42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s42 RCSB], [https://www.ebi.ac.uk/pdbsum/8s42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s42 ProSAT]</span></td></tr>
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[[Category: Arkin, M.R]]
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</table>
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[[Category: Overmans, M]]
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== Function ==
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[[Category: Pennings, M.A.M]]
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[[Category: Virta, J]]
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__TOC__
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[[Category: Visser, E.J]]
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</StructureSection>
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[[Category: Neitz, J]]
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[[Category: Homo sapiens]]
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[[Category: Ottmann, C]]
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[[Category: Large Structures]]
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[[Category: Oetelaar, M.C.M]]
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[[Category: Arkin MR]]
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[[Category: Brunsveld, L]]
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[[Category: Brunsveld L]]
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[[Category: Vickery, H]]
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[[Category: Konstantinidou M]]
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[[Category: Neitz J]]
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[[Category: Oetelaar MCM]]
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[[Category: Ottmann C]]
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[[Category: Overmans M]]
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[[Category: Pennings MAM]]
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[[Category: Vickery H]]
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[[Category: Virta J]]
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[[Category: Visser EJ]]

Current revision

Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 80 (1124898)

PDB ID 8s42

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OCA

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