8xvu

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Current revision (06:14, 15 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xvu is ON HOLD until Paper Publication
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==Structure of CXCR2 bound to CXCL2 (Ligand-receptor focused map)==
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<StructureSection load='8xvu' size='340' side='right'caption='[[8xvu]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
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Authors: Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xvu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XVU FirstGlance]. <br>
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Description: Structure of CXCR2 bound to CXCL2 (Ligand-receptor focused map)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.09&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xvu OCA], [https://pdbe.org/8xvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xvu RCSB], [https://www.ebi.ac.uk/pdbsum/8xvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xvu ProSAT]</span></td></tr>
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[[Category: Saha, S]]
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</table>
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[[Category: Shukla, A.K]]
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== Disease ==
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[[Category: Banerjee, R]]
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[https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency.
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[[Category: Ganguly, M]]
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== Function ==
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[[Category: Sharma, S]]
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[https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
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[[Category: Sano, F.K]]
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__TOC__
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[[Category: Shihoya, W]]
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</StructureSection>
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[[Category: Nureki, O]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Banerjee R]]
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[[Category: Ganguly M]]
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[[Category: Nureki O]]
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[[Category: Saha S]]
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[[Category: Sano FK]]
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[[Category: Sharma S]]
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[[Category: Shihoya W]]
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[[Category: Shukla AK]]

Current revision

Structure of CXCR2 bound to CXCL2 (Ligand-receptor focused map)

PDB ID 8xvu

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OCA

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