8yr3

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'''Unreleased structure'''
 
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The entry 8yr3 is ON HOLD until Paper Publication
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==Cryo-EM structure of the human ABCB6 in complex with Cd(II):GSH==
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<StructureSection load='8yr3' size='340' side='right'caption='[[8yr3]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors: Choi, S.H., Lee, S.S., Lee, H.Y., Kim, S., Kim, J.W., Jin, M.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8yr3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YR3 FirstGlance]. <br>
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Description: Cryo-EM structure of the human ABCB6 in complex with Cd(II):GSH
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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[[Category: Kim, J.W]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yr3 OCA], [https://pdbe.org/8yr3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yr3 RCSB], [https://www.ebi.ac.uk/pdbsum/8yr3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yr3 ProSAT]</span></td></tr>
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[[Category: Jin, M.S]]
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</table>
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[[Category: Lee, H.Y]]
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== Disease ==
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[[Category: Kim, S]]
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[https://www.uniprot.org/uniprot/ABCB6_HUMAN ABCB6_HUMAN] Ocular coloboma;Dyschromatosis universalis;Colobomatous microphthalmia. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. ABCB6 mutations are involved in familial pseudohyperkalemia, a dominantly inherited condition characterized by increased serum potassium levels, measured in whole-blood specimens stored at or below room temperature. This condition is not accompanied by clinical symptoms or biological signs except for borderline abnormalities of red cell shape (PubMed:23180570).<ref>PMID:23180570</ref>
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[[Category: Lee, S.S]]
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== Function ==
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[[Category: Choi, S.H]]
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[https://www.uniprot.org/uniprot/ABCB6_HUMAN ABCB6_HUMAN] Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.<ref>PMID:10837493</ref> <ref>PMID:17006453</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Choi SH]]
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[[Category: Jin MS]]
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[[Category: Kim JW]]
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[[Category: Kim S]]
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[[Category: Lee HY]]
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[[Category: Lee SS]]

Current revision

Cryo-EM structure of the human ABCB6 in complex with Cd(II):GSH

PDB ID 8yr3

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OCA

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