8zml

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'''Unreleased structure'''
 
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The entry 8zml is ON HOLD
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==Structure of TNIK with inhibitor==
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<StructureSection load='8zml' size='340' side='right'caption='[[8zml]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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Authors: Fan, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8zml]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZML FirstGlance]. <br>
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Description: Structure of TNIK with inhibitor
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.489&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D8H:2-[5-(4-fluorophenyl)-3-propan-2-yl-imidazol-4-yl]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-1~{H}-imidazole-4-carboxamide'>A1D8H</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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[[Category: Fan, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zml OCA], [https://pdbe.org/8zml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zml RCSB], [https://www.ebi.ac.uk/pdbsum/8zml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zml ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TNIK_HUMAN TNIK_HUMAN] Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.<ref>PMID:10521462</ref> <ref>PMID:15342639</ref> <ref>PMID:19061864</ref> <ref>PMID:19816403</ref> <ref>PMID:20159449</ref> <ref>PMID:21690388</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fan Y]]

Current revision

Structure of TNIK with inhibitor

PDB ID 8zml

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