9bw9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Tetrameric Complex of full-length HIV-1 integrase protein bound to the integrase binding domain of LEDGF/p75== | |
| - | + | <StructureSection load='9bw9' size='340' side='right'caption='[[9bw9]], [[Resolution|resolution]] 4.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9bw9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/HIV-1_06TG.HT008 HIV-1 06TG.HT008] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BW9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bw9 OCA], [https://pdbe.org/9bw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bw9 RCSB], [https://www.ebi.ac.uk/pdbsum/9bw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bw9 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: HIV-1 06TG HT008]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Biswas A]] | ||
| + | [[Category: Jing T]] | ||
| + | [[Category: Lyumkis D]] | ||
| + | [[Category: Shan Z]] | ||
Current revision
Tetrameric Complex of full-length HIV-1 integrase protein bound to the integrase binding domain of LEDGF/p75
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