1sg3

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[[Image:1sg3.gif|left|200px]]
 
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==Structure of allantoicase==
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The line below this paragraph, containing "STRUCTURE_1sg3", creates the "Structure Box" on the page.
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<StructureSection load='1sg3' size='340' side='right'caption='[[1sg3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sg3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SG3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sg3 OCA], [https://pdbe.org/1sg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sg3 RCSB], [https://www.ebi.ac.uk/pdbsum/1sg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sg3 ProSAT]</span></td></tr>
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{{STRUCTURE_1sg3| PDB=1sg3 | SCENE= }}
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</table>
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== Function ==
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'''Structure of allantoicase'''
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[https://www.uniprot.org/uniprot/ALLC_YEAST ALLC_YEAST] Utilization of purines as secondary nitrogen sources, when primary sources are limiting.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Allantoicase (EC 3.5.3.4) catalyzes the conversion of allantoate into ureidoglycolate and urea, one of the final steps in the degradation of purines to urea. The mechanism of most enzymes involved in this pathway, which has been known for a long time, is unknown. In this paper we describe the three-dimensional crystal structure of the yeast allantoicase determined at a resolution of 2.6 A by single anomalous diffraction. This constitutes the first structure for an enzyme of this pathway. The structure reveals a repeated jelly roll beta-sheet motif, also present in proteins of unrelated biochemical function. Allantoicase has a hexameric arrangement in the crystal (dimer of trimers). Analysis of the protein sequence against the structural data reveals the presence of two totally conserved surface patches, one on each jelly roll motif. The hexameric packing concentrates these patches into conserved pockets that probably constitute the active site.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sg/1sg3_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1SG3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG3 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sg3 ConSurf].
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Crystal structure of yeast allantoicase reveals a repeated jelly roll motif., Leulliot N, Quevillon-Cheruel S, Sorel I, Graille M, Meyer P, Liger D, Blondeau K, Janin J, van Tilbeurgh H, J Biol Chem. 2004 May 28;279(22):23447-52. Epub 2004 Mar 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15020593 15020593]
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<div style="clear:both"></div>
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[[Category: Allantoicase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Blondeau K]]
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[[Category: Blondeau, K.]]
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[[Category: Graille M]]
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[[Category: Graille, M.]]
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[[Category: Janin J]]
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[[Category: Janin, J.]]
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[[Category: Leulliot N]]
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[[Category: Leulliot, N.]]
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[[Category: Liger D]]
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[[Category: Liger, D.]]
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[[Category: Meyer P]]
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[[Category: Meyer, P.]]
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[[Category: Quevillon-Cheruel S]]
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[[Category: Quevillon-Cheruel, S.]]
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[[Category: Sorel I]]
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[[Category: Sorel, I.]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Tilbeurgh, H van.]]
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[[Category: Allantoicase]]
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[[Category: Hexamer]]
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[[Category: Jelly roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:39:35 2008''
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Current revision

Structure of allantoicase

PDB ID 1sg3

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