1sjy

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[[Image:1sjy.gif|left|200px]]
 
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==Crystal Structure of NUDIX HYDROLASE DR1025 FROM DEINOCOCCUS RADIODURANS==
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The line below this paragraph, containing "STRUCTURE_1sjy", creates the "Structure Box" on the page.
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<StructureSection load='1sjy' size='340' side='right'caption='[[1sjy]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sjy OCA], [https://pdbe.org/1sjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sjy RCSB], [https://www.ebi.ac.uk/pdbsum/1sjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sjy ProSAT], [https://www.topsan.org/Proteins/BSGC/1sjy TOPSAN]</span></td></tr>
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{{STRUCTURE_1sjy| PDB=1sjy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y1025_DEIRA Y1025_DEIRA] Hydrolase that can act as a nucleoside triphosphatase and a dinucleoside polyphosphate pyrophosphatase. The best substrates are 8-oxo-dGTP and 8-oxo-GTP. Other substrates include Ap4A, dGTP and GTP. May be involved in protection from damage caused by radiation.<ref>PMID:23481913</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sjy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sjy ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of NUDIX HYDROLASE DR1025 FROM DEINOCOCCUS RADIODURANS'''
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==See Also==
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*[[Nudix hydrolase 3D structures|Nudix hydrolase 3D structures]]
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== References ==
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==Overview==
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<references/>
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We have determined the crystal structure, at 1.4A, of the Nudix hydrolase DR1025 from the extremely radiation resistant bacterium Deinococcus radiodurans. The protein forms an intertwined homodimer by exchanging N-terminal segments between chains. We have identified additional conserved elements of the Nudix fold, including the metal-binding motif, a kinked beta-strand characterized by a proline two positions upstream of the Nudix consensus sequence, and participation of the N-terminal extension in the formation of the substrate-binding pocket. Crystal structures were also solved of DR1025 crystallized in the presence of magnesium and either a GTP analog or Ap(4)A (both at 1.6A resolution). In the Ap(4)A co-crystal, the electron density indicated that the product of asymmetric hydrolysis, ATP, was bound to the enzyme. The GTP analog bound structure showed that GTP was bound almost identically as ATP. Neither nucleoside triphosphate was further cleaved.
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__TOC__
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</StructureSection>
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==About this Structure==
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1SJY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJY OCA].
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==Reference==
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Structural studies of the Nudix hydrolase DR1025 from Deinococcus radiodurans and its ligand complexes., Ranatunga W, Hill EE, Mooster JL, Holbrook EL, Schulze-Gahmen U, Xu W, Bessman MJ, Brenner SE, Holbrook SR, J Mol Biol. 2004 May 21;339(1):103-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15123424 15123424]
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[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Category: Bessman MJ]]
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[[Category: Bessman, M J.]]
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[[Category: Brenner SE]]
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[[Category: Brenner, S E.]]
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[[Category: Hill EE]]
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[[Category: Hill, E E.]]
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[[Category: Holbrook EL]]
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[[Category: Holbrook, E L.]]
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[[Category: Holbrook SR]]
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[[Category: Holbrook, S R.]]
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[[Category: Mooster JL]]
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[[Category: Mooster, J L.]]
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[[Category: Ranatunga W]]
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[[Category: Ranatunga, W.]]
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[[Category: Schulze-Gahmen U]]
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[[Category: Schulze-Gahmen, U.]]
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[[Category: Xu W]]
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[[Category: Xu, W.]]
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[[Category: Alpha-beta-alpha sandwich]]
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[[Category: Berkeley structural genomics center]]
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[[Category: Bsgc structure funded by nih]]
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[[Category: Nudix fold]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:47:54 2008''
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Current revision

Crystal Structure of NUDIX HYDROLASE DR1025 FROM DEINOCOCCUS RADIODURANS

PDB ID 1sjy

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