9fb8

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'''Unreleased structure'''
 
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The entry 9fb8 is ON HOLD until Paper Publication
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==XChem refined PIF1-x0076 complex==
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<StructureSection load='9fb8' size='340' side='right'caption='[[9fb8]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9fb8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FB8 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.727&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O0J:~{N}-[4-(2-azanyl-1,3-thiazol-4-yl)phenyl]ethanamide'>O0J</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fb8 OCA], [https://pdbe.org/9fb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fb8 RCSB], [https://www.ebi.ac.uk/pdbsum/9fb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fb8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIF1_HUMAN PIF1_HUMAN] DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.[HAMAP-Rule:MF_03176]<ref>PMID:16522649</ref> <ref>PMID:17172855</ref> <ref>PMID:17827721</ref> <ref>PMID:18835853</ref> <ref>PMID:19700773</ref> <ref>PMID:20524933</ref> <ref>PMID:23657261</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Antson AA]]
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[[Category: Bax BD]]
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[[Category: Brandao-Neto J]]
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[[Category: Sanders CM]]

Current revision

XChem refined PIF1-x0076 complex

PDB ID 9fb8

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OCA

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