Crystallin
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== Function == | == Function == | ||
| - | '''Crystallin''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. '''α-, β-, γ-, δ-crystallin''' are named according to the order they are eluted by gel filtration. | + | '''Crystallin''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. '''α-, β-, γ-, δ-crystallin''' are named according to the order they are eluted by gel filtration. |
| - | See [[Alpha crystallin]]. | + | *'''Alpha crystallin''' has chaperone-like properties like the ability to prevent precipitation of denatured proteins<ref>PMID:15575808</ref>. See [[Alpha crystallin]]. |
| + | *'''Gamma crystallin''' is found mainly in the nuclear region of the lens<ref>PMID:26116913</ref>. | ||
| + | *.''' δ-crystallin''' is found in avian and reptilian lenses and missing from fish, amphibia and mammals lenses<ref>PMID:6369110</ref>. | ||
== Disease == | == Disease == | ||
| - | Several human cataracts have been linked to mutations in γ-D-crystallin<ref>PMID:11371638</ref>. | + | Mutations in α-A-crystallin and α-B-crystallin can cause myopathy<ref>PMID:12565801</ref>. Several human cataracts have been linked to mutations in γ-D-crystallin<ref>PMID:11371638</ref>. |
== 3D Structures of Crystallin == | == 3D Structures of Crystallin == | ||
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References
- ↑ Augusteyn RC. alpha-crystallin: a review of its structure and function. Clin Exp Optom. 2004 Nov;87(6):356-66. doi: 10.1111/j.1444-0938.2004.tb03095.x. PMID:15575808 doi:http://dx.doi.org/10.1111/j.1444-0938.2004.tb03095.x
- ↑ Vendra VP, Khan I, Chandani S, Muniyandi A, Balasubramanian D. Gamma crystallins of the human eye lens. Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):333-43. PMID:26116913 doi:10.1016/j.bbagen.2015.06.007
- ↑ Piatigorsky J. Delta crystallins and their nucleic acids. Mol Cell Biochem. 1984;59(1-2):33-56. PMID:6369110 doi:10.1007/BF00231304
- ↑ Horwitz J. Alpha-crystallin. Exp Eye Res. 2003 Feb;76(2):145-53. doi: 10.1016/s0014-4835(02)00278-6. PMID:12565801 doi:http://dx.doi.org/10.1016/s0014-4835(02)00278-6
- ↑ Pande A, Pande J, Asherie N, Lomakin A, Ogun O, King J, Benedek GB. Crystal cataracts: human genetic cataract caused by protein crystallization. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6116-20. PMID:11371638 doi:http://dx.doi.org/10.1073/pnas.101124798
