8zrt
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Cryo-EM structure focused on the receptor of the ET-1 bound ETBR-DNGI complex== |
| - | + | <StructureSection load='8zrt' size='340' side='right'caption='[[8zrt]], [[Resolution|resolution]] 3.62Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8zrt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZRT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.62Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zrt OCA], [https://pdbe.org/8zrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zrt RCSB], [https://www.ebi.ac.uk/pdbsum/8zrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zrt ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN] Hirschsprung disease;Waardenburg-Shah syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Defects in EDNRB are associated with Waardenburg syndrome 2, with ocular albinism, autosomal recessive: A disorder characterized by the association of features typical of Waardenburg syndrome type 2 with ocular albinism. Patients manifest reduced visual acuity, albinotic fundus, deafness, hypomelanosis.<ref>PMID:28236341</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN] Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:7536888</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Doi T]] | ||
| + | [[Category: Hall M]] | ||
| + | [[Category: Hamaguchi T]] | ||
| + | [[Category: Humbel BM]] | ||
| + | [[Category: Kanno R]] | ||
| + | [[Category: Maki-Yonekura S]] | ||
| + | [[Category: Mizoguchi A]] | ||
| + | [[Category: Negami T]] | ||
| + | [[Category: Tani K]] | ||
| + | [[Category: Terada T]] | ||
| + | [[Category: Yonekura K]] | ||
Current revision
Cryo-EM structure focused on the receptor of the ET-1 bound ETBR-DNGI complex
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Categories: Homo sapiens | Large Structures | Doi T | Hall M | Hamaguchi T | Humbel BM | Kanno R | Maki-Yonekura S | Mizoguchi A | Negami T | Tani K | Terada T | Yonekura K
