9f6z
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human N-deacetylase/N-sulfotransferase 1 homodimer== | |
| - | + | <StructureSection load='9f6z' size='340' side='right'caption='[[9f6z]], [[Resolution|resolution]] 4.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9f6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9F6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9F6Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9f6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9f6z OCA], [https://pdbe.org/9f6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9f6z RCSB], [https://www.ebi.ac.uk/pdbsum/9f6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9f6z ProSAT]</span></td></tr> |
| - | [[Category: Lortat-Jacob | + | </table> |
| - | [[Category: Vallet | + | == Function == |
| - | [[Category: Wild | + | [https://www.uniprot.org/uniprot/NDST1_HUMAN NDST1_HUMAN] Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.<ref>PMID:10758005</ref> <ref>PMID:12634318</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lortat-Jacob H]] | ||
| + | [[Category: Vallet SD]] | ||
| + | [[Category: Wild R]] | ||
Current revision
Human N-deacetylase/N-sulfotransferase 1 homodimer
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