9fkw

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m (Protected "9fkw" [edit=sysop:move=sysop])
Current revision (11:00, 18 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9fkw is ON HOLD
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==compound 3a bound KMT9 crystal structure==
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<StructureSection load='9fkw' size='340' side='right'caption='[[9fkw]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
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Authors: Sheng, W., Eric, M., Roland, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9fkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FKW FirstGlance]. <br>
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Description: compound 3a bound KMT9 crystal structure
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.392&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IDY:(2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-(methylamino)propyl]amino]-2-azanyl-butanoic+acid'>A1IDY</scene></td></tr>
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[[Category: Roland, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fkw OCA], [https://pdbe.org/9fkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fkw RCSB], [https://www.ebi.ac.uk/pdbsum/9fkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fkw ProSAT]</span></td></tr>
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[[Category: Sheng, W]]
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</table>
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[[Category: Eric, M]]
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== Function ==
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[https://www.uniprot.org/uniprot/N6MT1_HUMAN N6MT1_HUMAN] Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008). Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:30017583). N(6)-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (PubMed:30017583). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655).[UniProtKB:Q6SKR2]<ref>PMID:18539146</ref> <ref>PMID:20606008</ref> <ref>PMID:21193388</ref> <ref>PMID:25997655</ref> <ref>PMID:30017583</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Eric M]]
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[[Category: Roland S]]
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[[Category: Sheng W]]

Current revision

compound 3a bound KMT9 crystal structure

PDB ID 9fkw

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