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9flo
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9flo is ON HOLD Authors: Kraemer, A., Paruch, K., Knapp, S., Structural Genomics Consortium (SGC) Description: Crystal structure of human Haspin (G...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Haspin (GSG2) kinase bound to MU2181== | |
| - | + | <StructureSection load='9flo' size='340' side='right'caption='[[9flo]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9flo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FLO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9flo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9flo OCA], [https://pdbe.org/9flo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9flo RCSB], [https://www.ebi.ac.uk/pdbsum/9flo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9flo ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Kraemer A]] | ||
| + | [[Category: Paruch K]] | ||
Current revision
Crystal structure of human Haspin (GSG2) kinase bound to MU2181
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