9flr
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9flr is ON HOLD Authors: Kraemer, A., Paruch, K., Knapp, S., Structural Genomics Consortium (SGC) Description: Crystal structure of human Haspin (G...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Haspin (GSG2) kinase bound to MU1963== | |
| - | + | <StructureSection load='9flr' size='340' side='right'caption='[[9flr]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9flr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FLR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IDE:5-(1-methylpyrazol-4-yl)-3-pyridin-4-yl-1~{H}-pyrazolo[1,5-a]pyrimidin-8-ium'>A1IDE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9flr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9flr OCA], [https://pdbe.org/9flr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9flr RCSB], [https://www.ebi.ac.uk/pdbsum/9flr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9flr ProSAT]</span></td></tr> |
| - | [[Category: Knapp | + | </table> |
| - | [[Category: Kraemer | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Kraemer A]] | ||
| + | [[Category: Paruch K]] | ||
Current revision
Crystal structure of human Haspin (GSG2) kinase bound to MU1963
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