Ectonucleoside triphosphate diphosphohydrolase

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*'''NTPDase 1''' hydrolyzes ATP released by neutrophils<ref>PMID:18713747</ref>.
*'''NTPDase 1''' hydrolyzes ATP released by neutrophils<ref>PMID:18713747</ref>.
*'''NTPDase 2''' hydrolyzes extracellular ATP <ref>PMID:35593054</ref>.
*'''NTPDase 2''' hydrolyzes extracellular ATP <ref>PMID:35593054</ref>.
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*'''NTPDase 3''' hydrolyzes ATP in pancreatic beta-cells<ref>PMID:24085034</ref>.
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*'''NTPDase 4''' hydrolyzes ATP in Golgi bodies<ref>PMID:32767432</ref>.
</StructureSection>
</StructureSection>
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*NTPDase1
*NTPDase1
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**[[3zx3]] – rNTPDase extracellular domain - rat<br />
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**[[3zx0]], [[3zx2]] – rNTPDase extracellular domain + polyoxometallates <br />
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**[[5u7p]] – cNTPDase - clover<br />
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**[[5u7v]] – cNTPDase + AMP <br />
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**[[5u7w]] – cNTPDase + adenine <br />
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**[[5u7x]] – NTPDase - ''Vigna unguiculata''<br />
**[[3aap]] – LpNTPDase – ''Legionella pneumophila''<br />
**[[3aap]] – LpNTPDase – ''Legionella pneumophila''<br />
**[[3aaq]] – LpNTPDase + inhibitor<br />
**[[3aaq]] – LpNTPDase + inhibitor<br />
**[[3aar]] – LpNTPDase + AMPPNP<br />
**[[3aar]] – LpNTPDase + AMPPNP<br />
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**[[3zx3]] – rNTPDase extracellular domain - rat<br />
 
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**[[3zx0]], [[3zx2]] – rNTPDase extracellular domain + polyoxometallates <br />
 
**[[4jep]] – TgNTPDase – ''Toxoplasma gondii''<br />
**[[4jep]] – TgNTPDase – ''Toxoplasma gondii''<br />
**[[4a5b]] – TgNTPDase (mutant) <br />
**[[4a5b]] – TgNTPDase (mutant) <br />

Current revision

Structure of NTDPase1 complex with GMPPNP, Na+ (purple), Cl- (large green), Mg+2 (small green) ions (PDB code 4brg).

Drag the structure with the mouse to rotate

3D structures of ectonucleoside triphosphate diphosphohydrolase

Updated on 06-May-2025

References

  1. ↑ Zebisch M, Krauss M, Schafer P, Lauble P, Strater N. Crystallographic Snapshots along the Reaction Pathway of Nucleoside Triphosphate Diphosphohydrolases. Structure. 2013 Jul 2. pii: S0969-2126(13)00200-1. doi:, 10.1016/j.str.2013.05.016. PMID:23830739 doi:10.1016/j.str.2013.05.016
  2. ↑ Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem. 2008 Oct 17;283(42):28480-6. PMID:18713747 doi:10.1074/jbc.M800039200
  3. ↑ Dragic M, Mihajlovic K, Adzic M, Jakovljevic M, Kontic MZ, Mitrović N, Laketa D, Lavrnja I, Kipp M, Grković I, Nedeljkovic N. Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro. ASN Neuro. 2022 Jan-Dec;14:17590914221102068. PMID:35593054 doi:10.1177/17590914221102068
  4. ↑ Syed SK, Kauffman AL, Beavers LS, Alston JT, Farb TB, Ficorilli J, Marcelo MC, Brenner MB, Bokvist K, Barrett DG, Efanov AM. Ectonucleotidase NTPDase3 is abundant in pancreatic β-cells and regulates glucose-induced insulin secretion. Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1319-26. PMID:24085034 doi:10.1152/ajpendo.00328.2013
  5. ↑ Gorelik A, Labriola JM, Illes K, Nagar B. Crystal structure of the nucleotide-metabolizing enzyme NTPDase4. Protein Sci. 2020 Aug 6. doi: 10.1002/pro.3926. PMID:32767432 doi:http://dx.doi.org/10.1002/pro.3926

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Michal Harel, Alexander Berchansky

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