1sp3

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[[Image:1sp3.jpg|left|200px]]
 
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==Crystal structure of octaheme cytochrome c from Shewanella oneidensis==
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The line below this paragraph, containing "STRUCTURE_1sp3", creates the "Structure Box" on the page.
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<StructureSection load='1sp3' size='340' side='right'caption='[[1sp3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sp3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_oneidensis_MR-1 Shewanella oneidensis MR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SP3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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{{STRUCTURE_1sp3| PDB=1sp3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sp3 OCA], [https://pdbe.org/1sp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sp3 RCSB], [https://www.ebi.ac.uk/pdbsum/1sp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sp3 ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of octaheme cytochrome c from Shewanella oneidensis'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q8E9W8_SHEON Q8E9W8_SHEON]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/1sp3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sp3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
We have isolated a soluble cytochrome from Shewanella oneidensis that contains eight covalently attached heme groups and determined its crystal structure. One of these hemes exhibits novel ligation of the iron atom by the epsilon-amino group of a lysine residue, despite its attachment via a typical CXXCH motif. This heme is most likely the active site for tetrathionate reduction, a reaction catalyzed efficiently by this enzyme.
We have isolated a soluble cytochrome from Shewanella oneidensis that contains eight covalently attached heme groups and determined its crystal structure. One of these hemes exhibits novel ligation of the iron atom by the epsilon-amino group of a lysine residue, despite its attachment via a typical CXXCH motif. This heme is most likely the active site for tetrathionate reduction, a reaction catalyzed efficiently by this enzyme.
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==About this Structure==
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Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation.,Mowat CG, Rothery E, Miles CS, McIver L, Doherty MK, Drewette K, Taylor P, Walkinshaw MD, Chapman SK, Reid GA Nat Struct Mol Biol. 2004 Oct;11(10):1023-4. Epub 2004 Sep 7. PMID:15361860<ref>PMID:15361860</ref>
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1SP3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SP3 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation., Mowat CG, Rothery E, Miles CS, McIver L, Doherty MK, Drewette K, Taylor P, Walkinshaw MD, Chapman SK, Reid GA, Nat Struct Mol Biol. 2004 Oct;11(10):1023-4. Epub 2004 Sep 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15361860 15361860]
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</div>
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[[Category: Bacteria]]
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<div class="pdbe-citations 1sp3" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Chapman, S K.]]
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<references/>
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[[Category: Doherty, M K.]]
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__TOC__
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[[Category: Drewette, K.]]
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</StructureSection>
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[[Category: McIver, L.]]
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[[Category: Large Structures]]
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[[Category: Miles, C S.]]
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[[Category: Shewanella oneidensis MR-1]]
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[[Category: Mowat, C G.]]
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[[Category: Chapman SK]]
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[[Category: Reid, G A.]]
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[[Category: Doherty MK]]
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[[Category: Rothery, E.]]
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[[Category: Drewette K]]
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[[Category: Taylor, P.]]
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[[Category: McIver L]]
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[[Category: Walkinshaw, M D.]]
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[[Category: Miles CS]]
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[[Category: Cytochrome c]]
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[[Category: Mowat CG]]
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[[Category: Octaheme]]
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[[Category: Reid GA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:58:25 2008''
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[[Category: Rothery E]]
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[[Category: Taylor P]]
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[[Category: Walkinshaw MD]]

Current revision

Crystal structure of octaheme cytochrome c from Shewanella oneidensis

PDB ID 1sp3

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