Sandbox 1eve
From Proteopedia
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==Example page for E2020-TcAChE complex (1eve)== | ==Example page for E2020-TcAChE complex (1eve)== | ||
| - | <StructureSection load='1eve' size='340' side='right' caption='PDB entry [[1eve]]' scene=' | + | <StructureSection load='1eve' size='340' side='right' caption='PDB entry [[1eve]]' scene='29/2908/1eve_e20_cartoon/3'> |
[[Image:1eve.Workshop.jpg|thumb|left|250px|E2020 with active site and interacts]] | [[Image:1eve.Workshop.jpg|thumb|left|250px|E2020 with active site and interacts]] | ||
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== Introduction == | == Introduction == | ||
E2020, marketed as Aricept, is a member of a large family of N-benzylpiperidine- based acetylcholinesterase (AChE) inhibitors developed, synthesized and evaluated by the Elsai Company in Japan. These Inhibitors were designed on the basis of QSAR studies, prior to elucidation of the three-dimensional structure of Torpedo californica AChE (TCAChE). It significantly enhances performance in animal models of cholinergic hypofunction and has a high affinity for AChE. binding to both electric eel and mouse AChE in the nanomolar range. | E2020, marketed as Aricept, is a member of a large family of N-benzylpiperidine- based acetylcholinesterase (AChE) inhibitors developed, synthesized and evaluated by the Elsai Company in Japan. These Inhibitors were designed on the basis of QSAR studies, prior to elucidation of the three-dimensional structure of Torpedo californica AChE (TCAChE). It significantly enhances performance in animal models of cholinergic hypofunction and has a high affinity for AChE. binding to both electric eel and mouse AChE in the nanomolar range. | ||
| - | <scene name='10/1052408/ | + | <scene name='10/1052408/E2020_and_aricept/3'>E2020 and TcAChE</scene>. |
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== Exploring the Structure == | == Exploring the Structure == | ||
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<ref>PMID:10368299</ref> | <ref>PMID:10368299</ref> | ||
| + | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Example page for E2020-TcAChE complex (1eve)
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