1ssk

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[[Image:1ssk.gif|left|200px]]
 
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==Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein==
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The line below this paragraph, containing "STRUCTURE_1ssk", creates the "Structure Box" on the page.
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<StructureSection load='1ssk' size='340' side='right'caption='[[1ssk]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ssk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ssk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssk OCA], [https://pdbe.org/1ssk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ssk RCSB], [https://www.ebi.ac.uk/pdbsum/1ssk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssk ProSAT]</span></td></tr>
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{{STRUCTURE_1ssk| PDB=1ssk | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_SARS NCAP_SARS] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).[HAMAP-Rule:MF_04096]<ref>PMID:17210170</ref> <ref>PMID:18055455</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ss/1ssk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ssk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site.
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'''Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein'''
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Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein.,Huang Q, Yu L, Petros AM, Gunasekera A, Liu Z, Xu N, Hajduk P, Mack J, Fesik SW, Olejniczak ET Biochemistry. 2004 May 25;43(20):6059-63. PMID:15147189<ref>PMID:15147189</ref>
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==Overview==
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The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1SSK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA].
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</div>
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<div class="pdbe-citations 1ssk" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein., Huang Q, Yu L, Petros AM, Gunasekera A, Liu Z, Xu N, Hajduk P, Mack J, Fesik SW, Olejniczak ET, Biochemistry. 2004 May 25;43(20):6059-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15147189 15147189]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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[[Category: Human sars coronavirus]]
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== References ==
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[[Category: Single protein]]
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<references/>
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[[Category: Fesik, S W.]]
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__TOC__
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[[Category: Gunasekera, A.]]
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</StructureSection>
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[[Category: Hajduk, P.]]
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[[Category: Large Structures]]
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[[Category: Huang, Q.]]
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[[Category: Severe acute respiratory syndrome-related coronavirus]]
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[[Category: Liu, Z.]]
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[[Category: Fesik SW]]
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[[Category: Mack, J.]]
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[[Category: Gunasekera A]]
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[[Category: Olejniczak, E T.]]
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[[Category: Hajduk P]]
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[[Category: Petros, A M.]]
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[[Category: Huang Q]]
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[[Category: Xu, N.]]
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[[Category: Liu Z]]
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[[Category: Yu, L.]]
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[[Category: Mack J]]
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[[Category: Nucleocapsid protein]]
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[[Category: Olejniczak ET]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:05:33 2008''
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[[Category: Petros AM]]
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[[Category: Xu N]]
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[[Category: Yu L]]

Current revision

Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein

PDB ID 1ssk

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