9ftl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Asgard ESCRT-IIIB filament structure== | |
| + | <StructureSection load='9ftl' size='340' side='right'caption='[[9ftl]], [[Resolution|resolution]] 2.91Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9ftl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Heimdallarchaeota_archaeon Candidatus Heimdallarchaeota archaeon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FTL FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.91Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ftl OCA], [https://pdbe.org/9ftl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ftl RCSB], [https://www.ebi.ac.uk/pdbsum/9ftl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ftl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1Q9PC98_9ARCH A0A1Q9PC98_9ARCH] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | ESCRT-III proteins assemble into composite polymers that undergo stepwise changes in composition and structure to deform membranes across the tree of life. Here, using a phylogenetic analysis, we demonstrate that the two endosomal sorting complex required for transport III (ESCRT-III) proteins present in eukaryote's closest Asgard archaeal relatives are evolutionarily related to the B- and A-type eukaryotic paralogs that initiate and execute membrane remodeling, respectively. We show that Asgard ESCRT-IIIB assembles into parallel arrays on planar membranes to initiate membrane deformation, from where it recruits ESCRT-IIIA to generate composite polymers. Last, we show that Asgard ESCRT-IIIA is able to remodel membranes into tubes as a likely prelude to scission. Together, these data reveal a set of conserved principles governing ESCRT-III-dependent membrane remodeling that first emerged in a two-component ESCRT-III system in archaea. | ||
| - | + | Asgard archaea reveal the conserved principles of ESCRT-III membrane remodeling.,Souza DP, Espadas J, Chaaban S, Moody ERR, Hatano T, Balasubramanian M, Williams TA, Roux A, Baum B Sci Adv. 2025 Feb 7;11(6):eads5255. doi: 10.1126/sciadv.ads5255. Epub 2025 Feb 7. PMID:39919172<ref>PMID:39919172</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 9ftl" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Candidatus Heimdallarchaeota archaeon]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baum B]] | ||
| + | [[Category: Chaaban S]] | ||
| + | [[Category: Souza DP]] | ||
Current revision
Asgard ESCRT-IIIB filament structure
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