1wgr

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(New page: 200px<br /> <applet load="1wgr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wgr" /> '''Solution Structure of the RA Domain of Huma...)
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[[Image:1wgr.gif|left|200px]]<br />
 
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<applet load="1wgr" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1wgr" />
 
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'''Solution Structure of the RA Domain of Human Grb7 Protein'''<br />
 
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==About this Structure==
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==Solution Structure of the RA Domain of Human Grb7 Protein==
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1WGR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WGR OCA].
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<StructureSection load='1wgr' size='340' side='right'caption='[[1wgr]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1wgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WGR FirstGlance]. <br>
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[[Category: Inoue, M.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Kigawa, T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wgr OCA], [https://pdbe.org/1wgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wgr RCSB], [https://www.ebi.ac.uk/pdbsum/1wgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wgr ProSAT], [https://www.topsan.org/Proteins/RSGI/1wgr TOPSAN]</span></td></tr>
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[[Category: Koshiba, S.]]
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</table>
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[[Category: Li, H.]]
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== Function ==
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[https://www.uniprot.org/uniprot/GRB7_HUMAN GRB7_HUMAN] Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).<ref>PMID:10893408</ref> <ref>PMID:12021278</ref> <ref>PMID:12223469</ref> <ref>PMID:20622016</ref>
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[[Category: Tomizawa, T.]]
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== Evolutionary Conservation ==
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[[Category: Yokoyama, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: grb7]]
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Check<jmol>
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[[Category: ra domain]]
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<jmolCheckbox>
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[[Category: riken structural genomics/proteomics initiative]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/1wgr_consurf.spt"</scriptWhenChecked>
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[[Category: rsgi]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: structural genomics]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wgr ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:50:31 2007''
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==See Also==
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*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Li H]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama S]]

Current revision

Solution Structure of the RA Domain of Human Grb7 Protein

PDB ID 1wgr

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