1whb

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(New page: 200px<br /> <applet load="1whb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1whb" /> '''Solution structure of the Rhodanese-like do...)
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[[Image:1whb.gif|left|200px]]<br />
 
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<applet load="1whb" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1whb" />
 
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'''Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)'''<br />
 
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==About this Structure==
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==Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)==
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1WHB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Ubiquitin_thiolesterase Ubiquitin thiolesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.15 3.1.2.15] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WHB OCA].
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<StructureSection load='1whb' size='340' side='right'caption='[[1whb]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1whb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHB FirstGlance]. <br>
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[[Category: Ubiquitin thiolesterase]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Inoue, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whb OCA], [https://pdbe.org/1whb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whb RCSB], [https://www.ebi.ac.uk/pdbsum/1whb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whb ProSAT], [https://www.topsan.org/Proteins/RSGI/1whb TOPSAN]</span></td></tr>
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[[Category: Kigawa, T.]]
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</table>
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[[Category: Koshiba, S.]]
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== Function ==
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[https://www.uniprot.org/uniprot/UBP8_HUMAN UBP8_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.<ref>PMID:9628861</ref> <ref>PMID:16520378</ref> <ref>PMID:17711858</ref> <ref>PMID:18329369</ref>
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[[Category: Saito, K.]]
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== Evolutionary Conservation ==
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[[Category: Yokoyama, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: deubiqutinating enzyme]]
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Check<jmol>
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[[Category: riken structural genomics/proteomics initiative]]
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<jmolCheckbox>
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[[Category: rsgi]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1whb_consurf.spt"</scriptWhenChecked>
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[[Category: structural genomics]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: ubpy]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1whb ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:50:56 2007''
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Saito K]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)

PDB ID 1whb

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