Nucleoside triphosphatase
From Proteopedia
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'''Nucleoside triphosphatase''' or '''nucleoside triphosphate diphosphohydrolase''' (NTPase) is responsible for degradation of nucleotides to their monophosphate form. NTPase is found in mammals and in pathogenic microbes. In mammals NTPase hs a crucial role in regulation of purinergic signalling by hydrolysis of extracellular nucleotides. The function of NTPase in pathogens is still unknown<ref>PMID:24115522</ref>. | '''Nucleoside triphosphatase''' or '''nucleoside triphosphate diphosphohydrolase''' (NTPase) is responsible for degradation of nucleotides to their monophosphate form. NTPase is found in mammals and in pathogenic microbes. In mammals NTPase hs a crucial role in regulation of purinergic signalling by hydrolysis of extracellular nucleotides. The function of NTPase in pathogens is still unknown<ref>PMID:24115522</ref>. | ||
| + | *'''Nucleoside triphosphatase Nudi''' catalyses the hydrolysis of preferentially dUTP, dTTP and dCTP. | ||
== Relevance == | == Relevance == | ||
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==3D structures of nucleoside triphosphatase== | ==3D structures of nucleoside triphosphatase== | ||
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[[Nucleoside triphosphatase 3D structures]] | [[Nucleoside triphosphatase 3D structures]] | ||
| - | *Nucleoside triphosphatase 1 | ||
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| - | **[[4a57]] - TgNTPase 1 - ''Toxoplasma gondii'' <br /> | ||
| - | **[[4a59]] - TgNTPase 1 + AMP<br /> | ||
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| - | *Nucleoside triphosphatase 2 | ||
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| - | **[[4jep]] - TgNTPase 2 <br /> | ||
| - | **[[4a5b]] - TgNTPase 2 (mutant)<br /> | ||
| - | **[[4kh4]], [[4a5a]] - TgNTPase 2 (mutant) + AMPPNP<br /> | ||
| - | **[[4kh5]], [[4kh6]] - TgNTPase 2 (mutant) + AMPNP<br /> | ||
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| - | *Nucleoside triphosphatase Nudi | ||
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| - | **[[6dt3]] - Nudi - ''Klebsiella pneumoniae'' <br /> | ||
| - | **[[3oga]], [[3n77]] - Nudi - ''Salmonella enterica'' <br /> | ||
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| - | *Nucleoside triphosphatase cancer-related | ||
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| - | **[[2i3b]] - NTPase - human- NMR <br /> | ||
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| - | *Nucleoside triphosphatase | ||
| - | **[[3s86]] - NTPase - ''Thermotoga maritima'' <br /> | ||
| - | **[[3agr]] - NTPase - ''Neospora caninum'' <br /> | ||
| - | **[[7aoh]] - NTPase I in transcribing complex - Vaccinia virus – Cryo EM <br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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