9cuw

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(New page: '''Unreleased structure''' The entry 9cuw is ON HOLD Authors: Silva, M., Dong, A., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC) Description: Cr...)
Current revision (04:04, 5 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9cuw is ON HOLD
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==Crystal Structure of SETDB1 Tudor domain in complex with UNC100013==
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<StructureSection load='9cuw' size='340' side='right'caption='[[9cuw]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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Authors: Silva, M., Dong, A., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9cuw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CUW FirstGlance]. <br>
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Description: Crystal Structure of SETDB1 Tudor domain in complex with UNC100013
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AZ6:(2E)-4-(dimethylamino)-N-(4-{[6-(dimethylamino)hexyl]amino}-2-{[5-(dimethylamino)pentyl]amino}quinazolin-6-yl)but-2-enamide'>A1AZ6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Silva, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cuw OCA], [https://pdbe.org/9cuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cuw RCSB], [https://www.ebi.ac.uk/pdbsum/9cuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cuw ProSAT]</span></td></tr>
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[[Category: Dong, A]]
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</table>
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[[Category: Edwards, A.M]]
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== Function ==
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[[Category: Halabelian, L]]
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[https://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
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[[Category: Structural Genomics Consortium (Sgc)]]
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== References ==
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[[Category: Arrowsmith, C.H]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Halabelian L]]
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[[Category: Silva M]]

Current revision

Crystal Structure of SETDB1 Tudor domain in complex with UNC100013

PDB ID 9cuw

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