9iya

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m (Protected "9iya" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 9iya is ON HOLD
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==Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex==
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<StructureSection load='9iya' size='340' side='right'caption='[[9iya]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9iya]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IYA FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L3E:4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{N}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{H}-quinoline-3-carboxamide'>A1L3E</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9iya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iya OCA], [https://pdbe.org/9iya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iya RCSB], [https://www.ebi.ac.uk/pdbsum/9iya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iya ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GPR55_HUMAN GPR55_HUMAN] G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935).<ref>PMID:19805329</ref> <ref>PMID:36142844</ref> <ref>PMID:36523570</ref> <ref>PMID:37544935</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chang H]]
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[[Category: Cherezov V]]
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[[Category: Hua T]]
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[[Category: Li XT]]
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[[Category: Liu ZJ]]
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[[Category: Shen L]]

Current revision

Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex

PDB ID 9iya

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OCA

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