9cyp

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(New page: '''Unreleased structure''' The entry 9cyp is ON HOLD Authors: Ebrahim, A., Perdikari, A., Woods, V.A., Lawler, K., Bounds, R., Singh, N.I., Mehlman, T., Riley, B.T., Sharma, S., Morris,...)
Current revision (13:10, 21 August 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9cyp is ON HOLD
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==Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)==
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<StructureSection load='9cyp' size='340' side='right'caption='[[9cyp]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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Authors: Ebrahim, A., Perdikari, A., Woods, V.A., Lawler, K., Bounds, R., Singh, N.I., Mehlman, T., Riley, B.T., Sharma, S., Morris, J.W., Keogh, J.M., Henning, E., Smith, M., Farooqi, I.S., Keedy, D.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9cyp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CYP FirstGlance]. <br>
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Description: Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cyp OCA], [https://pdbe.org/9cyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cyp RCSB], [https://www.ebi.ac.uk/pdbsum/9cyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cyp ProSAT]</span></td></tr>
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[[Category: Riley, B.T]]
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</table>
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[[Category: Keogh, J.M]]
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== Function ==
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[[Category: Singh, N.I]]
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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[[Category: Farooqi, I.S]]
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== References ==
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[[Category: Bounds, R]]
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<references/>
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[[Category: Lawler, K]]
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__TOC__
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[[Category: Henning, E]]
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</StructureSection>
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[[Category: Ebrahim, A]]
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[[Category: Homo sapiens]]
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[[Category: Sharma, S]]
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[[Category: Large Structures]]
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[[Category: Morris, J.W]]
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[[Category: Bounds R]]
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[[Category: Perdikari, A]]
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[[Category: Ebrahim A]]
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[[Category: Keedy, D.A]]
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[[Category: Farooqi IS]]
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[[Category: Smith, M]]
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[[Category: Henning E]]
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[[Category: Woods, V.A]]
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[[Category: Keedy DA]]
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[[Category: Mehlman, T]]
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[[Category: Keogh JM]]
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[[Category: Lawler K]]
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[[Category: Mehlman T]]
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[[Category: Morris JW]]
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[[Category: Perdikari A]]
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[[Category: Riley BT]]
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[[Category: Sharma S]]
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[[Category: Singh NI]]
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[[Category: Smith M]]
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[[Category: Woods VA]]

Current revision

Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)

PDB ID 9cyp

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