9d2m
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9d2m is ON HOLD Authors: Torrents de la Pena, A., Ward, A.B., de Paiva Froes Rocha, R. Description: map of hemagglutinin A/Sing/INFIMH/16 expressed...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Map of hemagglutinin A/Sing/INFIMH/16 expressed in 293F cells== | |
| - | + | <StructureSection load='9d2m' size='340' side='right'caption='[[9d2m]], [[Resolution|resolution]] 3.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9d2m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9D2M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: Torrents | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9d2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d2m OCA], [https://pdbe.org/9d2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d2m RCSB], [https://www.ebi.ac.uk/pdbsum/9d2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d2m ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/A0A2R4U2X2_9INFA A0A2R4U2X2_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[ARBA:ARBA00059860][RuleBase:RU003324] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Influenza A virus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Torrents de la Pena A]] | ||
| + | [[Category: Ward AB]] | ||
| + | [[Category: De Paiva Froes Rocha R]] | ||
Current revision
Map of hemagglutinin A/Sing/INFIMH/16 expressed in 293F cells
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