9j3p
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Pigment Epithelium-Derived Factor with Zinc Ions Crystallized in P2(1)2(1)2(1) Space Group== | |
| - | + | <StructureSection load='9j3p' size='340' side='right'caption='[[9j3p]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9j3p]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J3P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j3p OCA], [https://pdbe.org/9j3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j3p RCSB], [https://www.ebi.ac.uk/pdbsum/9j3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j3p ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/PEDF_HUMAN PEDF_HUMAN] Defects in SERPINF1 are the cause of osteogenesis imperfecta type 12 (OI12) [MIM:[https://omim.org/entry/613982 613982]. OI12 is a connective tissue disorder characterized by bone fragility, low bone mass, and recurrent fractures. OI12 is characterized by features compatible with osteogenesis imperfecta type III in the Sillence classification. Patients have normal grayish sclerae and fractures of long bones and severe vertebral compression fractures, with resulting deformities observed as early as the first year of life.<ref>PMID:21353196</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PEDF_HUMAN PEDF_HUMAN] Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.<ref>PMID:8226833</ref> <ref>PMID:7592790</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baksheeva VE]] | ||
| + | [[Category: Belousov AS]] | ||
| + | [[Category: Borshchevskiy VI]] | ||
| + | [[Category: Bukhdruker SS]] | ||
| + | [[Category: Bulgakov TK]] | ||
| + | [[Category: Chistyakov DV]] | ||
| + | [[Category: Permyakov SE]] | ||
| + | [[Category: Tsvetkov PO]] | ||
| + | [[Category: Zamyatnin AA]] | ||
| + | [[Category: Zernii EY]] | ||
| + | [[Category: Zinchenko DV]] | ||
Current revision
Human Pigment Epithelium-Derived Factor with Zinc Ions Crystallized in P2(1)2(1)2(1) Space Group
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