TRNA methyltransferase
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Structure of tRNA methyltransferase for N1 of guanine 37 complex with S-adenosylhomocysteine (PDB entry [[1uak]])' scene='55/553109/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Structure of tRNA methyltransferase for N1 of guanine 37 complex with S-adenosylhomocysteine (PDB entry [[1uak]])' scene='55/553109/Cv/1'> | ||
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== Function == | == Function == | ||
'''tRNA methyltransferase''' ('''Trm''') methylates specific positions on tRNA. tRNA methylation is a post-transcription modification. The methyl donor is S-adenosylmethionine (SAM) and the product is the methylated tRNA and S-adenosylhomocysteine (SAH)<ref>PMID:25626150</ref>. S-adenosylornithine or sinefugin (SFG) is an inhibitor of the reaction. | '''tRNA methyltransferase''' ('''Trm''') methylates specific positions on tRNA. tRNA methylation is a post-transcription modification. The methyl donor is S-adenosylmethionine (SAM) and the product is the methylated tRNA and S-adenosylhomocysteine (SAH)<ref>PMID:25626150</ref>. S-adenosylornithine or sinefugin (SFG) is an inhibitor of the reaction. | ||
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*'''Dual specificity tRNA methyltransferase Rlmn''' is an ''E. coli'' methyltransferase which modifies both ribosomal 23S RNA and tRNA<ref>PMID:22891362</ref>. | *'''Dual specificity tRNA methyltransferase Rlmn''' is an ''E. coli'' methyltransferase which modifies both ribosomal 23S RNA and tRNA<ref>PMID:22891362</ref>. | ||
| + | *'''METTL6''' modifies cytidine 32<ref>PMId:32923617</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
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==3D structures of tRNA methyltransferase== | ==3D structures of tRNA methyltransferase== | ||
[[tRNA methyltransferase 3D structures]] | [[tRNA methyltransferase 3D structures]] | ||
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| - | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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