Tyrosine phosphatase
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
<StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' > | <StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' > | ||
| - | '''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>. PTPs are divided to 4 subfamilies. | + | __TOC__ |
| + | ==Function== | ||
| + | |||
| + | '''Tyrosine phosphatase''' or '''Protein tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>. PTPs are divided to 4 subfamilies. | ||
*'''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. Human '''PTP PRL''' is found in regenerating liver. | *'''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. Human '''PTP PRL''' is found in regenerating liver. | ||
| - | *'''PTP class II''' are low molecular weight PTP which dephosphorylate a number of growth factors and modulate their signalling processes<ref>PMID:27421795</ref>. | + | *'''PTP class II''' are low molecular weight PTP ('''LMW-PTP''') which dephosphorylate a number of growth factors and modulate their signalling processes<ref>PMID:27421795</ref>. |
*'''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. | *'''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. | ||
| - | *'''Non-receptor type PTPs''' are coded by the PTPN genes. <br /> | + | *'''Yersinia PTP''' see [[Yersinia YopH]].<br /> |
| + | *'''Non-receptor type PTPs''' are coded by the PTPN genes. <br /> | ||
| + | *'''T-cell PTP''' is a non-receptor type PTP expressed in hematopoietic tissues influencing most cells in the immune system<ref>PMID:19290937</ref>. | ||
| + | |||
For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]]. | For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]]. | ||
| Line 12: | Line 18: | ||
== 3D Structures of tyrosine phosphatase == | == 3D Structures of tyrosine phosphatase == | ||
[[Tyrosine phosphatase 3D structures]] | [[Tyrosine phosphatase 3D structures]] | ||
| - | |||
| - | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
