Wiskott-Aldrich syndrome protein
From Proteopedia
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== Function == | == Function == | ||
'''Wiskott-Aldrich syndrome protein''' (WASP) is involved in nucleating of new F-actin. In the autoinhibited form of WASP a region of the N-terminal interacts with a region of its C-terminal. This interaction is disrupted by CDC42 and phosphatidylinositol 4,5-bisphosphate (PIP2) resulting in the active WASP. WASP domains include '''EVH1''' domain in the N-terminal which bind proline-rich sequences in the WASP-interacting proteins; '''WH2''' domain is ca. 18 residues long and interacts with actin; '''CRIB or GTPase-binding''' domain which interacts with CDC42. | '''Wiskott-Aldrich syndrome protein''' (WASP) is involved in nucleating of new F-actin. In the autoinhibited form of WASP a region of the N-terminal interacts with a region of its C-terminal. This interaction is disrupted by CDC42 and phosphatidylinositol 4,5-bisphosphate (PIP2) resulting in the active WASP. WASP domains include '''EVH1''' domain in the N-terminal which bind proline-rich sequences in the WASP-interacting proteins; '''WH2''' domain is ca. 18 residues long and interacts with actin; '''CRIB or GTPase-binding''' domain which interacts with CDC42. | ||
| - | *'''N-WASP''' (Neural WASP) belongs to the WASP family of proteins. Human N-WASP stimulates the actin-nucleating activity<ref>PMID:22411869</ref>. | + | *'''N-WASP''' (Neural WASP) belongs to the WASP family of proteins. Human N-WASP stimulates the actin-nucleating activity<ref>PMID:22411869</ref>. |
| + | *'''WAVE-1''' facilitates neuronal actin remodeling<ref>PMID:17215396</ref>. | ||
| + | *'''WAVE-2''' facilitates cytoskeletal actin remodeling<ref>PMID:16401421</ref>. | ||
== Relevance == | == Relevance == | ||
Current revision
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