9g8q

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Current revision (04:20, 17 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9g8q is ON HOLD until Paper Publication
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==40S-bound human SKI238 complex in the open state (Gatekeeping module)==
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<StructureSection load='9g8q' size='340' side='right'caption='[[9g8q]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9g8q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9G8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9G8Q FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9g8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9g8q OCA], [https://pdbe.org/9g8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9g8q RCSB], [https://www.ebi.ac.uk/pdbsum/9g8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9g8q ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SKI2_HUMAN SKI2_HUMAN] Syndromic diarrhea. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SKI2_HUMAN SKI2_HUMAN] Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656).<ref>PMID:16024656</ref> <ref>PMID:32006463</ref> <ref>PMID:35120588</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Conti E]]
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[[Category: Keidel A]]
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[[Category: Koegel A]]
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[[Category: Kuhn CC]]
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[[Category: Langer LM]]
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[[Category: Loukeri MJ]]
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[[Category: Schaefer IB]]

Current revision

40S-bound human SKI238 complex in the open state (Gatekeeping module)

PDB ID 9g8q

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OCA

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