9gl6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==TRPC5 in complex with spin-labelled ligand SpinPico3== | |
| - | + | <StructureSection load='9gl6' size='340' side='right'caption='[[9gl6]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9gl6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GL6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IMP:7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-(1,1,3,3-tetramethyl-2-oxidanyl-isoindol-5-yl)oxy-purine-2,6-dione'>A1IMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> |
| - | [[Category: Bon | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gl6 OCA], [https://pdbe.org/9gl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gl6 RCSB], [https://www.ebi.ac.uk/pdbsum/9gl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gl6 ProSAT]</span></td></tr> |
| - | [[Category: Hammond | + | </table> |
| - | [[Category: Porav | + | == Function == |
| + | [https://www.uniprot.org/uniprot/TRPC5_HUMAN TRPC5_HUMAN] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).[UniProtKB:Q9QX29]<ref>PMID:16284075</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bon RS]] | ||
| + | [[Category: Hammond KLR]] | ||
| + | [[Category: Porav SA]] | ||
Current revision
TRPC5 in complex with spin-labelled ligand SpinPico3
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