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1t5q

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[[Image:1t5q.gif|left|200px]]
 
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==Solution Structure of GIP(1-30)amide in TFE/Water==
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The line below this paragraph, containing "STRUCTURE_1t5q", creates the "Structure Box" on the page.
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<StructureSection load='1t5q' size='340' side='right'caption='[[1t5q]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T5Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5q OCA], [https://pdbe.org/1t5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t5q RCSB], [https://www.ebi.ac.uk/pdbsum/1t5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t5q ProSAT]</span></td></tr>
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{{STRUCTURE_1t5q| PDB=1t5q | SCENE= }}
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</table>
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== Function ==
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'''Solution Structure of GIP(1-30)amide in TFE/Water'''
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[https://www.uniprot.org/uniprot/GIP_HUMAN GIP_HUMAN] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine the three-dimensional structure of the peptide. Therefore, to understand the basic structural requirements for the biological activity of GIP, the solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular modelling. The structure is characterised by a full length alpha-helical conformation between residues F(6) and A(28). This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists.
Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine the three-dimensional structure of the peptide. Therefore, to understand the basic structural requirements for the biological activity of GIP, the solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular modelling. The structure is characterised by a full length alpha-helical conformation between residues F(6) and A(28). This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists.
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==About this Structure==
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NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.,Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6. PMID:15522230<ref>PMID:15522230</ref>
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1T5Q is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide., Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP, Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15522230 15522230]
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</div>
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[[Category: Single protein]]
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<div class="pdbe-citations 1t5q" style="background-color:#fffaf0;"></div>
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[[Category: Alana, I.]]
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== References ==
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[[Category: Gault, V A.]]
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<references/>
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[[Category: Harte, F P.M O.]]
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__TOC__
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[[Category: Hewage, C M.]]
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</StructureSection>
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[[Category: Malthouse, J P.G.]]
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[[Category: Homo sapiens]]
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[[Category: Parker, J C.]]
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[[Category: Large Structures]]
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[[Category: Diabetes]]
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[[Category: Alana I]]
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[[Category: Gip]]
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[[Category: Gault VA]]
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[[Category: Helix]]
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[[Category: Hewage CM]]
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[[Category: Molecular modelling]]
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[[Category: Malthouse JPG]]
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[[Category: Nmr]]
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[[Category: O'Harte FPM]]
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[[Category: Obesity]]
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[[Category: Parker JC]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:33:38 2008''
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Current revision

Solution Structure of GIP(1-30)amide in TFE/Water

PDB ID 1t5q

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