9gng
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9gng is ON HOLD Authors: Lolicato, M., Arrigoni, C. Description: mouse VDAC1 in complex with MPD Category: Unreleased Structures [[Category: Ar...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==mouse VDAC1 in complex with MPD== | |
| - | + | <StructureSection load='9gng' size='340' side='right'caption='[[9gng]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9gng]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GNG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene></td></tr> |
| - | [[Category: Arrigoni | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gng OCA], [https://pdbe.org/9gng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gng RCSB], [https://www.ebi.ac.uk/pdbsum/9gng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gng ProSAT]</span></td></tr> |
| - | [[Category: Lolicato | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VDAC1_MOUSE VDAC1_MOUSE] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:10716730</ref> <ref>PMID:15477379</ref> <ref>PMID:18988731</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Arrigoni C]] | ||
| + | [[Category: Lolicato M]] | ||
Current revision
mouse VDAC1 in complex with MPD
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