High mobility group protein
From Proteopedia
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<StructureSection load='2gzk' size='340' side='right' caption='Rat HMGB1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''> | <StructureSection load='2gzk' size='340' side='right' caption='Rat HMGB1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''> | ||
== Function == | == Function == | ||
| - | '''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and | + | '''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulates transcription. HMG superfamilies differ by their DNA-binding domains.<br /> |
* '''HMGA'''s bind via an AT-hook domain. For details on HMGA see [[HMGI(Y)]].<br /> | * '''HMGA'''s bind via an AT-hook domain. For details on HMGA see [[HMGI(Y)]].<br /> | ||
* '''HMGB'''s bind via box domain<ref>PMID:17979838</ref>.<br /> | * '''HMGB'''s bind via box domain<ref>PMID:17979838</ref>.<br /> | ||
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**[[6cij]], [[6cik]], [[6cil]], [[6cim]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA<br /> | **[[6cij]], [[6cik]], [[6cil]], [[6cim]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA<br /> | ||
**[[6cg0]], [[6oem]], [[6oen]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br /> | **[[6cg0]], [[6oem]], [[6oen]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br /> | ||
| + | **[[8i9m]] – hHMG-1 89-183 + RAGE – Cryo EM<br /> | ||
| + | **[[9cg9]] – hHMG-1 + nucleosome – Cryo EM<br /> | ||
**[[2eqz]], [[2yqi]] – hHMG-3 box domain - NMR<br /> | **[[2eqz]], [[2yqi]] – hHMG-3 box domain - NMR<br /> | ||
**[[1j3d]] – pHMG-2 C terminal – pig - NMR<br /> | **[[1j3d]] – pHMG-2 C terminal – pig - NMR<br /> | ||
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**[[1ckt]], [[4qr9]] – rHMG-1 A domain + DNA <br /> | **[[1ckt]], [[4qr9]] – rHMG-1 A domain + DNA <br /> | ||
**[[2gzk]] – rHMG-1 tandem boxes + DNA <br /> | **[[2gzk]] – rHMG-1 tandem boxes + DNA <br /> | ||
| - | **[[ | + | **[[5zdz]], [[5ze0]], [[5ze1]], [[5ze2]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse<br /> |
**[[6oeo]], [[6oer]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br /> | **[[6oeo]], [[6oer]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br /> | ||
**[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG-1 box domain – chinese hamster - NMR <br /> | **[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG-1 box domain – chinese hamster - NMR <br /> | ||
Current revision
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3D Structures of high mobility group protein (HMG)
Updated on 26-August-2025
References
- ↑ Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev. 2007 Dec;220:35-46. PMID:17979838 doi:http://dx.doi.org/10.1111/j.1600-065X.2007.00574.x
- ↑ Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001 Oct;22(10):1583-91. PMID:11576996
- ↑ Tang D, Kang R, Zeh HJ 3rd, Lotze MT. High-mobility group box 1 and cancer. Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):131-40. doi:, 10.1016/j.bbagrm.2009.11.014. PMID:20123075 doi:http://dx.doi.org/10.1016/j.bbagrm.2009.11.014
