High mobility group protein

From Proteopedia

Current revision

spinqualitylabelsall models Rat HMGB1 tandem boxes complexed with DNA (PDB code 2gzk). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function High mobility group protein (HMG) is a chromatin protein which organizes the DNA and regulates transcription. HMG superfamilies differ by their DNA-binding domains. HMGAs bind via an AT-hook domain. For details on HMGA see HMGI(Y). HMGBs bind via box domain[1]. HMGNs bind via a nucleosome binding domain. Disease Rearrangements of the HMGA2 gene were detected in human benign lipoma tumors[2]. Relevance Overexpression of HMGB1 is associated with cancer and is targeted for cancer therapy[3]. Structural highlights

3D Structures of high mobility group protein (HMG)

Updated on 26-August-2025

References

1. ↑ Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev. 2007 Dec;220:35-46. PMID:17979838 doi:http://dx.doi.org/10.1111/j.1600-065X.2007.00574.x
2. ↑ Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001 Oct;22(10):1583-91. PMID:11576996
3. ↑ Tang D, Kang R, Zeh HJ 3rd, Lotze MT. High-mobility group box 1 and cancer. Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):131-40. doi:, 10.1016/j.bbagrm.2009.11.014. PMID:20123075 doi:http://dx.doi.org/10.1016/j.bbagrm.2009.11.014