9iyq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human GluN1-N2B NMDA receptors in the Mg2+ free state== | |
| - | + | <StructureSection load='9iyq' size='340' side='right'caption='[[9iyq]], [[Resolution|resolution]] 3.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9iyq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IYQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.18Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RC:(2~{R})-4-(3-phosphonopropyl)piperazine-2-carboxylic+acid'>7RC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9iyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iyq OCA], [https://pdbe.org/9iyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iyq RCSB], [https://www.ebi.ac.uk/pdbsum/9iyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iyq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NMDZ1_HUMAN NMDZ1_HUMAN] Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:[https://omim.org/entry/614254 614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21376300</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NMDZ1_HUMAN NMDZ1_HUMAN] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Huang X]] | ||
| + | [[Category: Sun X]] | ||
| + | [[Category: Zhu S]] | ||
Current revision
Structure of the human GluN1-N2B NMDA receptors in the Mg2+ free state
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Categories: Homo sapiens | Large Structures | Huang X | Sun X | Zhu S
