1t8c

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[[Image:1t8c.gif|left|200px]]
 
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==Structure of the C-type lectin domain of CD23==
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The line below this paragraph, containing "STRUCTURE_1t8c", creates the "Structure Box" on the page.
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<StructureSection load='1t8c' size='340' side='right'caption='[[1t8c]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T8C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8c OCA], [https://pdbe.org/1t8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t8c RCSB], [https://www.ebi.ac.uk/pdbsum/1t8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t8c ProSAT]</span></td></tr>
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{{STRUCTURE_1t8c| PDB=1t8c | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t8/1t8c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t8c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response. We have determined the three-dimensional structure of the C-type lectin domain of CD23 in solution by nuclear magnetic resonance spectroscopy. An analysis of concentration-dependent chemical shift perturbations have allowed us to identify the residues engaged in self-association to the trimeric state, whereas ligand-induced changes have defined the binding sites for IgE and CD21. The results further reveal that CD23 can bind both ligands simultaneously. Despite the C-type lectin domain structure, none of the interactions require calcium. We also find that IgE and CD23 can interact to form high molecular mass multimeric complexes. The interactions that we have described provide a solution to the paradox that CD23 is involved in both up- and down-regulation of IgE and provide a structural basis for the development of inhibitors of allergic disease.
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'''Structure of the C-type lectin domain of CD23'''
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The structure of human CD23 and its interactions with IgE and CD21.,Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM J Exp Med. 2005 Sep 19;202(6):751-60. PMID:16172256<ref>PMID:16172256</ref>
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==Overview==
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The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response. We have determined the three-dimensional structure of the C-type lectin domain of CD23 in solution by nuclear magnetic resonance spectroscopy. An analysis of concentration-dependent chemical shift perturbations have allowed us to identify the residues engaged in self-association to the trimeric state, whereas ligand-induced changes have defined the binding sites for IgE and CD21. The results further reveal that CD23 can bind both ligands simultaneously. Despite the C-type lectin domain structure, none of the interactions require calcium. We also find that IgE and CD23 can interact to form high molecular mass multimeric complexes. The interactions that we have described provide a solution to the paradox that CD23 is involved in both up- and down-regulation of IgE and provide a structural basis for the development of inhibitors of allergic disease.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1T8C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8C OCA].
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</div>
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<div class="pdbe-citations 1t8c" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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The structure of human CD23 and its interactions with IgE and CD21., Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM, J Exp Med. 2005 Sep 19;202(6):751-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16172256 16172256]
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*[[CD23|CD23]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gould, H J.]]
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[[Category: Gould HJ]]
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[[Category: Grundy, G J.]]
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[[Category: Grundy GJ]]
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[[Category: Hibbert, R G.]]
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[[Category: Hibbert RG]]
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[[Category: McDonnell, J M.]]
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[[Category: McDonnell JM]]
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[[Category: Sutton, B J.]]
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[[Category: Sutton BJ]]
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[[Category: Teriete, P.]]
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[[Category: Teriete P]]
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[[Category: C-type lectin]]
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[[Category: Fc receptor]]
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[[Category: Fcerii]]
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[[Category: Ige]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:39:46 2008''
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Current revision

Structure of the C-type lectin domain of CD23

PDB ID 1t8c

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