9j6g
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Bat SARS-like coronavirus Khosta-1 spike protein== | |
| - | + | <StructureSection load='9j6g' size='340' side='right'caption='[[9j6g]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9j6g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bat_SARS-like_coronavirus_Khosta-1 Bat SARS-like coronavirus Khosta-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J6G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j6g OCA], [https://pdbe.org/9j6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j6g RCSB], [https://www.ebi.ac.uk/pdbsum/9j6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j6g ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/A0A8E6M825_9BETC A0A8E6M825_9BETC] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] |
| - | [[Category: Qi | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Bat SARS-like coronavirus Khosta-1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gao GF]] | ||
| + | [[Category: Li LJ]] | ||
| + | [[Category: Liu KF]] | ||
| + | [[Category: Pan XQ]] | ||
| + | [[Category: Qi JX]] | ||
Current revision
Cryo-EM structure of Bat SARS-like coronavirus Khosta-1 spike protein
| |||||||||||
