We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
9jmb
From Proteopedia
(Difference between revisions)
m (Protected "9jmb" [edit=sysop:move=sysop]) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of HSV-2 gB and FAB 16F9 complex== | |
| - | + | <StructureSection load='9jmb' size='340' side='right'caption='[[9jmb]], [[Resolution|resolution]] 2.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9jmb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_2 Human alphaherpesvirus 2] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JMB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.18Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jmb OCA], [https://pdbe.org/9jmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jmb RCSB], [https://www.ebi.ac.uk/pdbsum/9jmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jmb ProSAT]</span></td></tr> |
| - | [[Category: Li | + | </table> |
| - | [[Category: Li | + | == Function == |
| - | [[Category: Zheng | + | [https://www.uniprot.org/uniprot/Q89920_HHV2 Q89920_HHV2] Envelope glycoprotein that forms spikes at the surface of virion envelope and binds to the host cell entry receptors MYH9/NMMHC-IIA and MYH10/NMMHC-IIB, promoting the virus entry into host cells. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell: following initial binding to its host cell entry receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).[ARBA:ARBA00055014] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human alphaherpesvirus 2]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Li S]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Zheng Q]] | ||
Current revision
Cryo-EM structure of HSV-2 gB and FAB 16F9 complex
| |||||||||||
