1x0n

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(New page: 200px<br /> <applet load="1x0n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x0n" /> '''NMR structure of growth factor receptor bin...)
Current revision (13:55, 9 May 2024) (edit) (undo)
 
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[[Image:1x0n.gif|left|200px]]<br />
 
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<applet load="1x0n" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1x0n" />
 
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'''NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor'''<br />
 
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==Disease==
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==NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor==
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Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]], Haddad syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]]
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<StructureSection load='1x0n' size='340' side='right'caption='[[1x0n]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X0N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTF:4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC+ACID'>DTF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x0n OCA], [https://pdbe.org/1x0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x0n RCSB], [https://www.ebi.ac.uk/pdbsum/1x0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x0n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x0/1x0n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x0n ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1X0N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with DTF as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X0N OCA].
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*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Burke, T.R.]]
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[[Category: Burke TR]]
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[[Category: Inagaki, F.]]
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[[Category: Inagaki F]]
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[[Category: Ogura, K.]]
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[[Category: Ogura K]]
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[[Category: Shiga, T.]]
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[[Category: Shiga T]]
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[[Category: Yokochi, M.]]
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[[Category: Yokochi M]]
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[[Category: Yuzawa, S.]]
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[[Category: Yuzawa S]]
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[[Category: DTF]]
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[[Category: peptide binding protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:57:25 2007''
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Current revision

NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor

PDB ID 1x0n

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