1x11

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(New page: 200px<br /> <applet load="1x11" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x11, resolution 2.5&Aring;" /> '''X11 PTB DOMAIN'''<br...)
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[[Image:1x11.gif|left|200px]]<br />
 
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<applet load="1x11" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1x11, resolution 2.5&Aring;" />
 
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'''X11 PTB DOMAIN'''<br />
 
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==Overview==
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==X11 PTB DOMAIN==
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The crystal structure of the phosphotyrosine-binding domain (PTB) of the, X11 protein has been determined, in complex with unphosphorylated peptides, corresponding to a region of beta-amyloid precursor protein (betaAPP) that, is required for receptor internalization. The mode of binding to X11 of, the unphosphorylated peptides, which contain an NPxY motif, resembles that, of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight, peptide residues make specific contacts with the X11 PTB domain, and they, collectively achieve high affinity (KD = 0.32 microM) and specificity., These results suggest that, in contrast to the SH2 domains, the PTB, domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.
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<StructureSection load='1x11' size='340' side='right'caption='[[1x11]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x11]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X11 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x11 OCA], [https://pdbe.org/1x11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x11 RCSB], [https://www.ebi.ac.uk/pdbsum/1x11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x11 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/1x11_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x11 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the unphosphorylated peptides, which contain an NPxY motif, resembles that of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight peptide residues make specific contacts with the X11 PTB domain, and they collectively achieve high affinity (KD = 0.32 microM) and specificity. These results suggest that, in contrast to the SH2 domains, the PTB domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.
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==Disease==
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Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.,Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J EMBO J. 1997 Oct 15;16(20):6141-50. PMID:9321393<ref>PMID:9321393</ref>
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Known diseases associated with this structure: Alzheimer disease-1, APP-related OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104760 104760]], Amyloidosis, cerebroarterial, Dutch type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104760 104760]], Amyloidosis, cerebroarterial, Iowa type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104760 104760]], Blood group, P system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607922 607922]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1X11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X11 OCA].
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</div>
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<div class="pdbe-citations 1x11" style="background-color:#fffaf0;"></div>
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==Reference==
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== References ==
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Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain., Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J, EMBO J. 1997 Oct 15;16(20):6141-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9321393 9321393]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Kuriyan, J.]]
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[[Category: Kuriyan J]]
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[[Category: Lee, C.H.]]
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[[Category: Lee C-H]]
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[[Category: Zhang, Z.]]
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[[Category: Zhang Z]]
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[[Category: complex (peptide binding module/peptide)]]
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[[Category: ptb domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:57:37 2007''
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Current revision

X11 PTB DOMAIN

PDB ID 1x11

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