9dss

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m (Protected "9dss" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 9dss is ON HOLD
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==Crystal structure of Fab 7088 in complex with NPNA3 peptide from circumsporozoite protein==
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<StructureSection load='9dss' size='340' side='right'caption='[[9dss]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Jain, M., Wilson, I.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9dss]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DSS FirstGlance]. <br>
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Description: Crystal structure of Fab 7088 in complex with NPNA3 peptide from circumsporozoite protein
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dss OCA], [https://pdbe.org/9dss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dss RCSB], [https://www.ebi.ac.uk/pdbsum/9dss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dss ProSAT]</span></td></tr>
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[[Category: Wilson, I.A]]
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</table>
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[[Category: Jain, M]]
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== Function ==
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[https://www.uniprot.org/uniprot/CSP_PLAF7 CSP_PLAF7] Essential sporozoite protein (PubMed:29554084, PubMed:32150583). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:29554084, PubMed:32150583). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity).[UniProtKB:P23093]<ref>PMID:29554084</ref> <ref>PMID:32150583</ref> In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.[UniProtKB:P23093]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Jain M]]
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[[Category: Wilson IA]]

Current revision

Crystal structure of Fab 7088 in complex with NPNA3 peptide from circumsporozoite protein

PDB ID 9dss

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