1x3s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1x3s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x3s, resolution 1.32&Aring;" /> '''Crystal structure o...)
Current revision (07:36, 30 October 2024) (edit) (undo)
 
(18 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1x3s.gif|left|200px]]<br />
 
-
<applet load="1x3s" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1x3s, resolution 1.32&Aring;" />
 
-
'''Crystal structure of human Rab18 in complex with Gppnhp'''<br />
 
-
==About this Structure==
+
==Crystal structure of human Rab18 in complex with Gppnhp==
-
1X3S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and GNP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X3S OCA].
+
<StructureSection load='1x3s' size='340' side='right'caption='[[1x3s]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[1x3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X3S FirstGlance]. <br>
-
[[Category: Chen, L.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
-
[[Category: Kukimoto-Niino, M.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
[[Category: Liu, Z.J.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x3s OCA], [https://pdbe.org/1x3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x3s RCSB], [https://www.ebi.ac.uk/pdbsum/1x3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x3s ProSAT], [https://www.topsan.org/Proteins/RSGI/1x3s TOPSAN]</span></td></tr>
-
[[Category: Murayama, K.]]
+
</table>
-
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+
== Disease ==
-
[[Category: Shirouzu, M.]]
+
[https://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN] Defects in RAB18 are the cause of Warburg micro syndrome type 3 (WARBM3) [MIM:[https://omim.org/entry/614222 614222]. WARBM3 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.<ref>PMID:21473985</ref>
-
[[Category: Wang, B.C.]]
+
== Function ==
-
[[Category: Yokoyama, S.]]
+
[https://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN] Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.<ref>PMID:21473985</ref>
-
[[Category: GNP]]
+
== Evolutionary Conservation ==
-
[[Category: MG]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: gnp]]
+
Check<jmol>
-
[[Category: gtpase]]
+
<jmolCheckbox>
-
[[Category: national project on protein structural and functional analyses]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/1x3s_consurf.spt"</scriptWhenChecked>
-
[[Category: nppsfa]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
-
[[Category: rab]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: riken structural genomics/proteomics initiative]]
+
</jmolCheckbox>
-
[[Category: rsgi]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x3s ConSurf].
-
[[Category: structural genomics]]
+
<div style="clear:both"></div>
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:58:17 2007''
+
==See Also==
 +
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 +
*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Chen L]]
 +
[[Category: Kukimoto-Niino M]]
 +
[[Category: Liu ZJ]]
 +
[[Category: Murayama K]]
 +
[[Category: Shirouzu M]]
 +
[[Category: Wang BC]]
 +
[[Category: Yokoyama S]]

Current revision

Crystal structure of human Rab18 in complex with Gppnhp

PDB ID 1x3s

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x3s"
Personal tools