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1tdk

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[[Image:1tdk.gif|left|200px]]
 
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==L-amino acid oxidase from Agkistrodon halys in complex with suicide substrate L-vinylglycine==
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The line below this paragraph, containing "STRUCTURE_1tdk", creates the "Structure Box" on the page.
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<StructureSection load='1tdk' size='340' side='right'caption='[[1tdk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tdk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=LVG:L-VINYLGLYCINE'>LVG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1tdk| PDB=1tdk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdk OCA], [https://pdbe.org/1tdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdk RCSB], [https://www.ebi.ac.uk/pdbsum/1tdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OXLA_GLOHA OXLA_GLOHA] Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). This protein induces apoptosis of cultured HeLa cells.<ref>PMID:15103157</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/td/1tdk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tdk ConSurf].
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<div style="clear:both"></div>
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'''L-amino acid oxidase from Agkistrodon halys in complex with suicide substrate L-vinylglycine'''
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==See Also==
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*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1TDK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDK OCA].
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__TOC__
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</StructureSection>
[[Category: Gloydius halys]]
[[Category: Gloydius halys]]
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[[Category: L-amino-acid oxidase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Niu L]]
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[[Category: Niu, L.]]
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[[Category: Teng M]]
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[[Category: Teng, M.]]
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[[Category: Zhang H]]
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[[Category: Zhang, H.]]
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[[Category: Complex structure with suicide substrate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:49:35 2008''
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Current revision

L-amino acid oxidase from Agkistrodon halys in complex with suicide substrate L-vinylglycine

PDB ID 1tdk

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OCA

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