1tfj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:39, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1tfj.gif|left|200px]]
 
-
<!--
+
==Crystal structure of Bovine Glycolipid transfer protein in complex with a fatty acid==
-
The line below this paragraph, containing "STRUCTURE_1tfj", creates the "Structure Box" on the page.
+
<StructureSection load='1tfj' size='340' side='right'caption='[[1tfj]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1tfj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TFJ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
{{STRUCTURE_1tfj| PDB=1tfj | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfj OCA], [https://pdbe.org/1tfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tfj RCSB], [https://www.ebi.ac.uk/pdbsum/1tfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfj ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Crystal structure of Bovine Glycolipid transfer protein in complex with a fatty acid'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/GLTP_BOVIN GLTP_BOVIN] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:10671554</ref> <ref>PMID:16309699</ref>
-
 
+
== Evolutionary Conservation ==
-
==Overview==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
Glycolipids participate in many important cellular processes and they are bound and transferred with high specificity by glycolipid transfer protein (GLTP). We have solved three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid. The 1.4 angstroms structure resembles the recently characterized apo-form of the human GLTP but the other two structures represent an intermediate conformation of the apo-GLTPs and the human lactosylceramide-bound GLTP structure. These novel structures give insight into the mechanism of lipid binding and how GLTP may conformationally adapt to different lipids. Furthermore, based on the structural comparison of the GLTP structures and the three-dimensional models of the related Podospora anserina HET-C2 and Arabidopsis thaliana accelerated cell death protein, ACD11, we give structural explanations for their specific lipid binding properties.
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tfj_consurf.spt"</scriptWhenChecked>
-
1TFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFJ OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==Reference==
+
</jmolCheckbox>
-
Structural evidence for adaptive ligand binding of glycolipid transfer protein., Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA, J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16309699 16309699]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tfj ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Airenne, T T.]]
+
[[Category: Airenne TT]]
-
[[Category: Kidron, H.]]
+
[[Category: Kidron H]]
-
[[Category: Mattjus, P.]]
+
[[Category: Mattjus P]]
-
[[Category: Nymalm, Y.]]
+
[[Category: Nymalm Y]]
-
[[Category: Salminen, T A.]]
+
[[Category: Salminen TA]]
-
[[Category: West, G.]]
+
[[Category: West G]]
-
[[Category: Glycolipid]]
+
-
[[Category: Lipid transport]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:53:29 2008''
+

Current revision

Crystal structure of Bovine Glycolipid transfer protein in complex with a fatty acid

PDB ID 1tfj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tfj"
Personal tools