1x4u

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(New page: 200px<br /> <applet load="1x4u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x4u" /> '''Solution structure of the FYVE domain from ...)
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[[Image:1x4u.gif|left|200px]]<br />
 
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<applet load="1x4u" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1x4u" />
 
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'''Solution structure of the FYVE domain from human FYVE domain containing 27 isoform b protein'''<br />
 
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==Disease==
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==Solution structure of the FYVE domain from human FYVE domain containing 27 isoform b protein==
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Known disease associated with this structure: Spastic paraplegia 33 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610243 610243]]
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<StructureSection load='1x4u' size='340' side='right'caption='[[1x4u]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1x4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X4U FirstGlance]. <br>
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1X4U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X4U OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4u OCA], [https://pdbe.org/1x4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x4u RCSB], [https://www.ebi.ac.uk/pdbsum/1x4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4u ProSAT], [https://www.topsan.org/Proteins/RSGI/1x4u TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ZFY27_HUMAN ZFY27_HUMAN] Defects in ZFYVE27 are the cause of spastic paraplegia autosomal dominant type 33 (SPG33) [MIM:[https://omim.org/entry/610244 610244]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=According to PubMed:18606302, the properties of the variant Val-191 and its frequency in some populations raise doubts on the implication of that gene in the disease.<ref>PMID:16826525</ref> <ref>PMID:18606302</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ZFY27_HUMAN ZFY27_HUMAN] Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.<ref>PMID:17082457</ref> <ref>PMID:19289470</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x4u ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: ZN]]
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[[Category: fyve domain]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: phosphoinositide binding]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: zinc binding]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:59:05 2007''
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Current revision

Solution structure of the FYVE domain from human FYVE domain containing 27 isoform b protein

PDB ID 1x4u

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OCA

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